Nothing is impossible for Unix and many of the users do not know how to run ASP.Net framework from cPanel.
With this article, I will teach you how to enable ASP.Net Framework from cPanel, but before that, you must be the server owner/administrator for the server that tried to install this and have/have not setup the server.
To run ASP.Net(.aspx) from Apache, you may install third party component to support the ASP.Net. cPanel included a feature called EasyApache and EasyApache allow user to install third party component named mod_mono and mono project that make the possible for ASP.Net run in Apache.
For more information for the support component from the Microsoft .Net Framework, please refer to the mono default web page, Mono Project.
To run EasyApache, run the following script from root by using shell will do.